CANTOR COLBURN LLP

CANTOR COLBURN LLP:1158742 [20-012950]

CANTOR COLBURN LLP:1158742 [20-012950]

FOR TECHNOLOGY TRANSFER OFFICE, PATENT PROSECUTION IN ORDER TO TO CONTINUE ONGOING PATENT WORK IN CHINA

CANTOR COLBURN LLP:1158742 [20-012950]

REVIEW OFFICE ACTION AND DEVELOP STRATEGY FOR RESPONDING. REFERENCE NO.: E -116-2016-0-JP-01, LAW FIRM DOCKET/MATTER NO.: NIH0108JPD2 IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0063-25 SIGNED AND DATED 7/31/2025.

THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CCL-CHM.0086-19;E-077-2019-0-US-01;NEWMAN;PATENT LEGAL SERVICE;(LUBET) CCL-CHM.0087-19;E-077-2019-0-US-01;NEWMAN;PATENT LEGAL SERVICE;(LUBET)

THIS SERVICE IS FOR LEGAL PATENT SERVICES FOR CHEMICALS. POP: 06/20/2025 TO 06/19/2026.

[25-010767] IC (NHLBI), UNDER CONTRACT NO. 75N98020D00060 REQUIRES THE VENDOR TO DRAFT AND FILE A PCT APPLICATION BASED ON THE PRIORITY CASE 63/663,336 IN ORDER TO SECURE PATENT PROTECTION FOR THE INVENTION DESCRIBED IN E-255-2023-0-PC-01.

CLOSE OUT

THIS WO NUMBER: 20CCL-CHM.0057-25DRAFT AND FINALIZE US AND FOREIGN APPLICATIONS E-128-2019-0-JP-06 LAW FIRM REFERENCE: NIH0145JP; LEAD INVENTOR: CRAIG THOMAS.

[25-007615] THE IC REQUIRES THE VENDOR TO PREPARE AND FILE A RESPONSE TO A RULE 161/162 COMMUNICATION FROM THE EUROPEAN PATENT OFFICE IN ORDER TO SECURE IP PROTECTION FOR THE INVENTION DESCRIBED IN E-100-2022-0-EP-01.

FY 20 EXPIRING LINES CCL-CHM.0053-19; E-041-2018-0-PCT-02; REINHOLD; PATENT LEGAL SERVICE; (CHANG)

FY 20 EXPIRING LINES THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0024-19; E-176-2015-1-US-01; ZHENG; PATENT LEGAL SERVICE; (ANTCZAK) CLN 2-CCL-CHM.0025-19; E-176-2015-1-US-01; ZHENG; PATENT L

FY 20 EXPIRING LINES CCL-CHM.0156-19;E-181-20182-PCT-01;POMMIER;PATENT LEGAL SERVICE; (CHANG)

DRAFT AND FILE PCT APPLICATION. REFERENCE NO.: E-262-2023-0-PC-01, LAW FIRM DOCKET/MATTER NO.: NIH0162PCT, IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0003-25 SIGNED AND DATED 11/1/2024.

[25-003714] IC (NHLBI), UNDER CONTRACT NO. 75N98020D00060 REQUIRES THE VENDOR TO PREPARE AND FILE A NATIONAL STAGE PATENT APPLICATION IN ORDER TO SECURE PATENT PROTECTION FOR THE INVENTION DESCRIBED IN E-110-2022-0-CN-01

REVIEW OFFICE ACTION AND DEVELOP STRATEGY FOR RESPONSE. REFERENCE NO.: E-128-2019-0-JP-06, LAW FIRM DOCKET/MATTER NO.: NIH0145JP, IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0011-25 SIGNED AND DATED 11/6/2024.

DRAFT AND FILE PCT APPLICATION. REFERENCE NO.: E-246-2023-0-PC-01, LAW FIRM DOCKET/MATTER NO.: NIH0163PCT, IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0009-25 SIGNED AND DATED 11/7/2024.

FY 20 EXPIRING LINES THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0001-20; E-150-2016-0-US-06; CHEN; PATENT LEGAL SERVICE; (SHMILOVICH) CLN 2-CCL-CHM.0003-20; E-150-2016-1-CN-02; CHEN; PATENT

FY 19 EXPIRING LINES THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0061-18; E-122-2018-0-US-01; WEISSMAN; PATENT LEGAL SERVICE; (ANTCZAK) CLN 2-CCL-CHM.0062-18; E-122-2018-0-US-01; WEISSMAN; PA

PATENT LEGAL SERVICES ISSUE FEE FOR PATENT APPLICATION

FY 19 EXPIRING LINES CCL-CHM.0038-19; E-189-2016-0-JP-08; BOXER; PATENT LEGAL SERVICE; (VEPA)

24-013488 NHLBI REQUIRES RESPONSE TO A EUROPEAN OFFICE ACTION IN ORDER TO ADVANCE PROTECTION OF CLAIMS COVERING ISOTOPES OF ALPHA-KETOGLUTARATE USED IN THE HYPERPOLARIZED MR IMAGING OF MULTIPLE CANCER TYPES.

PERFORM A CONFLICT OF INTEREST CHECK. REFERENCE NO.: E-145-2024-0-US-01, LAW FIRM DOCKET/MATTER NO.: NIH0165US, IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0048-24 SIGNED AND DATED 4/8/2024.

24-009518 IC (NHLBI), UNDER CONTRACT NO. 75N98020D00060, REQUIRES THE VENDOR TO PREPARE AND FILE A FULLY ENABLED PROVISIONAL APPLICATION IN ORDER TO SECURE PATENT PROTECTION FOR THE INVENTION DESCRIBED IN E-255-2023-0-US-01.

THIS IS FOR LEGAL PATENT SERVICES FOR 20CCL-CHM.0044-24; E-119-2021-0-US-01; SIBLEY; PATENT LEGAL SERVICE; (ANO) (PLEASE SEE MORE DETAILS IN THE ATTACHED TASK ORDER) POP: 03/18/2024 TO 03/17/2025

REVIEW OFFICE ACTION AND DEVELOP STRATEGY FOR RESPONDING. REFERENCE NO.: E-096-2018-0-JP-07, LAW FIRM DOCKET/MATTER NO.: NIH0132JP, IN ACCORDANCE WITH NIH TORFQ NO: 20CCL-CHM.0046-24 SIGNED AND DATED 3/8/2024.

FY 19 EXPIRING LINES THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0092-18; E-257-2010-0-AT-22; MARUGAN; PATENT LEGAL SERVICE; (VEPA) CLN 2-CCL-CHM.0093-18; E-257-2010-0-BE-23; MARUGAN; PATENT

NIDDK / LEGAL SERVICES

NIDDK / LAW FIRM WILL PREPARE AND FILE RESPONSE TO THE OFFICE ACTION PER THE TORFQ.

MODIFYING DELIVERY/TASK ORDER: 75N98020D00060/75N92023F00023 TO DE- OBLIGATE $1,062.00 REMAINING FUNDS. THE NEW TOTAL OBLIGATION IS $10,974.00. ORIGINAL LANGUAGE FOLLOWS. 23-012386 NIAAA, UNDER CONTRACT 75N98020D00060 (E-110-2022-0-PC-01) REQUIRES

FY 18 EXPIRING LINES CCL-CHM.0076-17; E-097-2017/0-EIR-00; STEVENS; PATENT LEGAL SERVICE; (ANTCZAK)

REVIEW OFFICE ACTION AND DEVELOP STRATEGY FOR RESPONDING. REFERENCE NO.: E-096-2018-0-JP-07, LAW FIRM DOCKET/MATTER NO.: NIH0132JP

[23-013982] NHLBI REQUIRES THE VENDOR TO DRAFT AND FILE A PCT APPLICATION IN ORDER TO SECURE PATENT PROTECTION FOR NIH REF. NO. E-100-2022-0-PCT-02.

REVIEW OFFICE ACTION AND DEVELOP STRATEGY FOR RESPONDING. REFERENCE NO.: E-116-2016-0-JP-11, LAW FIRM DOCKET/MATTER NO.: NIH0108JPD

CANTOR COLBURN LLP:1158742 [20-012949]

CANTOR COLBURN LLP:1158742 [23-012386] NIAAA, UNDER CONTRACT 75N98020D00060 (E-110-2022-0-PC-01) REQUIRES FILING A PATENT COOPERATION TREATY PATENT APPLICATION IN ORDER TO CONTINUE PATENT PROSECUTION FOR THE INVENTION REFERENCED IN E-110-2022

CANTOR COLBURN LLP:1158742 [20-012669]

REVIEW AND DEVELOP STRATEGY FOR RESPONDING TO OFFICE ACTION. REFERENCE NO.: E-101-2017-0-EP-07, LAW FIRM DOCKET/MATTER NO.: NIH0121EPD.

[23-010706] E-024-2018-0-IL-05 REQUIRES FILING A PETITION FOR REINSTATEMENT IN ORDER TO PRESERVE PATENT RIGHTS

PATENT LEGAL SERVICES

PATENT LEGAL SERVICES

[23-002763] NIAAA REQUIRES THE FILING OF AN INTERNATIONAL APPLICATION UNDER THE PATENT COOPERATION TREATY IN ORDER TO PURSUE INTERNATIONAL RIGHTS TO AN INVENTION PERTAINING TO PYRAZOLE COMPOUNDS THAT MAY HAVE ANTI-INFLAMMATORY AND ANTI-CANCER THERAPE

PREPARE AND VALIDATE A REGIONAL PATENT. REFERENCE NO.: E-072-2012-0-ES-08, LAW FIRM DOCKET/MATTER NO.: NIH0073ES.

[22-012115] NHLBI REQUIRES REQUIRES THE VENDOR TO PREPARE AND FILE A NATIONAL STAGE PATENT APPLICATION IN ORDER TO IN ORDER TO SECURE PATENT PROTECTION FOR THE INVENTION DESCRIBED IN E-070-2020-0-EP-03

[22-012112] NHLBI REQUIRES REQUIRES THE VENDOR TO PREPARE AND FILE A NATIONAL STAGE PATENT APPLICATION IN ORDER TO IN ORDER TO SECURE PATENT PROTECTION FOR THE INVENTION DESCRIBED IN E-069-2020-0-EP-03

CCL-CHM.0095-20; E-077-2019-0-PCT-02; GREIG; PATENT LEGAL SERVICE; (CHATTERJEE)

CCL-CHM.0030-20; E-165-2017-0-CN-03; OU; PATENT LEGAL SERVICE; (GIRARDS)

THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0074-20; E-097-2017-0-AU-03; STEVENS; PATENT LEGAL SERVICE; (ANTCZAK) CLN 2-CCL-CHM.0075-20; E-097-2017-0-CA-04; STEVENS; PATENT LEGAL SERVICE; (ANTC

THE CONTRACTOR SHALL PROVIDE PATENT-LEGAL SERVICES DESCRIBED IN THE ATTACHED TORFQS. CLN 1-CCL-CHM.0132-20; E-041-2018-0-EP-03; REINHOLD; PATENT LEGAL SERVICE: (CHANG) CLN 2-CCL-CHM.0133-20; E-041-2018-0-US-04; REINHOLD; PATENT LEGAL SERVICE: (CHAN