HOFFMANN-LA ROCHE INC.

THE PURPOSE OF THIS MODIFICATION IS ADD SUPPLEMENTAL FUNDING FOR CLIN 0001 & 0002 AND TO UPDATED THE PERIOD OF PERFORMANCE (POP) FOR CLIN 0001 TO END ON 12/31/2026.

THE PURPOSE OF THIS MODIFICATION IS TO UPDATE COST SHARE AMOUNT, EXTEND POP, UPDATE SOW, AND ADD SUPPLEMENTAL FUNDING TO CLIN 0002.

THE PURPOSE OF THIS MODIFICATION IS TO UPDATE COST SHARE AMOUNT AND ADD SUPPLEMENTAL FUNDING TO CLIN 0002.

THE PURPOSE OF THIS MODIFICATION IS TO UPDATE COST SHARE AMOUNT AND ADD SUPPLEMENTAL FUNDING TO CLIN 0002.

THE PURPOSE OF THIS MODIFICATION IS A NO COST EXTENSION, DE-OBLIGATE CANCELLING FUNDS, UPDATE COST SHARE AMOUNT, AND ADD SUPPLEMENTAL FUNDING TO CLIN 0002.

THE PURPOSE OF THIS MODIFICATION IS THE ADDITION OF SUPPLEMENTAL FUNDING OF $2,000,000 TO SUPPORT SOURCE DATA VERIFICATION, FULL ELECTRONIC MEDICAL RECORD UPLOADS, AND THE ADJUDICATION PROCESS FOR THE ONGOING REFERENCE RANGE AND CLINICAL PERFORMANCE

THE PURPOSE OF THIS MODIFICATION IS TO DE-OBLIGATE EXCESS AND CANCELLING FUNDS

THE PURPOSE OF THIS MODIFICATION IS TO: (1) UPDATE THE OTHER TRANSACTION AGREEMENTS OFFICER (OTAO); (2) DELETE ATTACHMENT 1, STATEMENT OF WORK, DATED SEPTEMBER 24, 2018 IN ITS ENTIRETY AND REPLACE IT WITH ATTACHMENT 1, STATEMENT OF WORK, DATED OCTOBE